Correlation of HbA1c with Lipid Profile in Type 2 Diabetes
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Abstract
Background: Type 2 diabetes mellitus (T2DM) is typically in line with dyslipidaemia, which substantially increases cardiovascular risk. Glycated haemoglobin (HbA1c) reflects long-term glycaemic control and has been proposed as a potential surrogate marker for lipid abnormalities. However, evidence regarding the correlation between HbA1c and lipid profile components remains inconsistent, particularly in Southeast Asian populations. This study aimed to evaluate the correlation between HbA1c levels and lipid profile parameters among patients with T2Dm treated at a tertiary referral hospital in Indonesia.
Methods: A cross-sectional analytic study was conducted using medical record data from 68 patients with T2DM. HbA1c levels and lipid profile parameters–including total cholesterol, high-density lipoprotein (HDL) cholesterol, low-density lipoprotein (LDL) cholesterol, and triglycerides–were analysed. Data normality was assessed using the Kolmogorov–Smirnov test. Spearman’s rank correlation test was applied to determine the correlation between HbA1c and lipid profile components.
Results: The median HbA1c level was 8.70% (range: 4.90–14.70%), indicating suboptimal glycaemic control. Median lipid profile values were 203.50 mg/dL for total cholesterol, 55.50 mg/dL for HDL cholesterol, 115.00 mg/dL for LDL cholesterol, and 138.50 mg/dL for triglycerides. Correlation analysis revealed no statistically significant association between HbA1c levels and any lipid profile component.
Conclusion: HbA1c levels were not significantly correlated with lipid profile parameters in patients with T2DM. These findings suggest that glycaemic control alone may not adequately reflect lipid-related cardiovascular risk, underscoring the need for comprehensive cardiometabolic assessment in patients with T2DM.
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References
World Health Organization. Diabetes [Internet]. 2024 [cited 2025 Feb 21].
Kumari M, Kumar V, Verma SK, Mahli RK. Evaluation of lipid profile and glycated haemoglobin in type 2 diabetic patients. Int J Health Sci (Qassim). 2022;6(2):4372–83.
International Diabetes Federation. IDF Diabetes Atlas 10th edition [Internet]. [cited 2025 Feb 21].
Goyal R, Singhal M, Jialal I. Type 2 Diabetes [Internet]. StatPearls Publishing; 2025 [cited 2025 Jun 20].
Farmaki P, Damaskos C, Garmpis N, Garmpi A, Savvanis S, Diamantis E. Complications of the Type 2 Diabetes Mellitus. Curr Cardiol Rev. 2020;16(4):249–51.
Rodriguez-Saldana J, editor. The Diabetes Textbook: Clinical Principles, Patient Management and Public Health Issues. 2nd ed. Mexico City: Springer Nature Switzerland AG; 2023.
Park HS, Cho Y, Seo DH, Ahn SH, Hong S, Suh YJ, et al. Impact of diabetes distress on glycemic control and diabetic complications in type 2 diabetes mellitus. Sci Rep. 2024;14(1):10545.
Melmed S, Auchus RJ, Goldfine AB, Rosen CJ, Kopp PA. Williams Textbook of Endocrinology. 15th ed. Elsevier; 2025. p. 1845.
Nyoman N, Haryanti T, Dewi R, Nia P, Santoso C. Korelasi antara kolesterol total dengan kadar HbA1c pada pasien diabetes mellitus tipe 2 di RSUD Tabanan Tahun 2021. Aesculapius Med J. 2023;3(2):112–7.
Julianto E, Silitonga HA, Siahaan JM. Does HbA1c correlate with lipid profile in type 2 diabetes mellitus? A new evidence from Medan, North Sumatera. Indones J Med. 2017;2(3):207–12.
Majumder M, Mollah FH, Ferdous SA. Association of HbA1c level with lipid profiles among type 2 diabetic patients attended at Medical University of Bangladesh. J Natl Inst Neurosci Bangladesh. 2019;5(1):72–5.
Zulfian, Anggraeni S, Prasetya T, Saputra I. Hubungan kadar HbA1c dengan kadar kolesterol total pada penderita diabetes melitus tipe 2 di Rumah Sakit Pertamina Bintang Amin Husada Bandar Lampung Tahun 2022. Medula. 2022;17(2):45–9.
Sharahili AY, Mir SA, AlDosari S, Manzar MD, Alshehri B, Al Othaim A, et al. Correlation of HbA1c level with lipid profile in type 2 diabetes mellitus patients visiting a primary healthcare center in Jeddah city, Saudi Arabia: A retrospective cross-sectional study. Diseases. 2023;11(4):154.
Wulandari AM, MAM. The relationship between HbA1c level and total cholesterol in type 2 diabetes patients. J La Medihealtico. 2025;6(1):85–93.
Fahira Chaidir A, Achmad K, Muchsin H, Makmun A, Rachman E, Iskandar D. Karakteristik penyandang diabetes melitus tipe 2. 2024. Report.
Aprilio R, Novia Arman W. Gambaran pasien diabetes melitus tipe 2. Jl. Raya Serang-Jkt No.KM [Internet]. Panancangan; 2025.
Mukonda E, van der Westhuizen DJ, Dave JA, Cleary S, Hannan L, Rusch JA, et al. Understanding the relationship between the frequency of HbA1c monitoring, HbA1c changes over time, and the achievement of targets: A retrospective cohort study. BMC Endocr Disord. 2025;25(1):45.
Hafid A, Suharmanto S. Hubungan antara kadar trigliserida dengan kadar HbA1c pada pasien DM tipe II. Jurnal Ilmiah Kesehatan Sandi Husada. 2021;10(2):469–74.
Sabrina Susilo A, Artini I. Korelasi nilai HbA1c dengan kadar kolesterol total pada pasien diabetes mellitus tipe 2. Jurnal Ilmiah Kesehatan Sandi Husada. 2020;9(2):640–5.
Yuliana Yusuf M, Irwanto Natadidjaja R. There is no relationship between HbA1c and HDL in type 2 diabetes mellitus patients. J Med Case Rep. 2024;7(10):1410–7.
Darmawan A, Maria I, Indah W, Aurora D, Kusdiyah E. Skrining HbA1c pada pasien diabetes melitus di wilayah kerja puskesmas Pakuan Baru Kota Jambi. MEDIC. 2022;15:436–9.
Ichlasia Haryati A, Ariguntar Wikaning Tyas T. Perbandingan kadar HbA1c pada pasien diabetes melitus tipe 2 yang disertai hipertensi dan tanpa hipertensi di rumah sakit. J Kedokteran Kesehatan. 2022.
He P, Gan X, Wu Q, Ye Z, Yang S, Zhang Y, et al. Joint effect of visit-to-visit variability in LDL-cholesterol, HDL-cholesterol, and HbA1c on cardiovascular and total mortality in patients with diabetes. Diabetol Metab Syndr. 2022;14(1):112.
Vergès B, Hdl L. New insight into the pathophysiology of lipid abnormalities in type 2 diabetes. Diabetes Metab. 2005;31(3):267–74.
Zhang H, Chen Y, Zhu W, Niu T, Song B, Wang H, et al. The mediating role of HbA1c in the association between elevated low-density lipoprotein cholesterol levels and diabetic peripheral neuropathy in patients with type 2 diabetes mellitus. Lipids Health Dis. 2023;22:112.
Adam LN. Association between dyslipidemia and glycated hemoglobin in diabetic patients from Zakho General Hospital, Iraq. Egypt J Intern Med. 2025;37(1):10–5.
Setyoadi S, Ismail DDSL, Kartika AW, Sari DP, Septian AD, Lallo AS, et al. The relationship between high-density lipoprotein (HDL) and glycated hemoglobin (HbA1c) in type 2 diabetes mellitus patients: Implications for cardiovascular risk. J Rural Community Nurs Pract. 2025;3(2):234–49.
Li K, Yang L, Zhao D. The relationship between HbA1c control pattern and atherosclerosis progression of diabetes: A prospective study of Chinese population. Diabetol Metab Syndr. 2024;16:215.
Lee S, Liu T, Zhou J, Zhang Q, Wong WT, Tse G. Predictions of diabetes complications and mortality using HbA1c variability: A 10-year observational cohort study. Acta Diabetol. 2021;58(2):171–80.
Abukhelaif AE, Alghamdi AH, Saeed Saadi Alghamdi K, Rashed Tami Alghamdi O, Safer Alghamdi M. Prevalence and pattern of dyslipidemia among patients with type II diabetes in Al-Baha, Saudi Arabia. Afr J Biomed Res. 2024;27(4S):6860–5.
Tramunt B, Smati S, Grandgeorge N, Lenfant F, Arnal JF, Montagner A, et al. Sex differences in metabolic regulation and diabetes susceptibility. Diabetologia. 2020;63(3):453–61.
He L. Metformin and systemic metabolism. Trends Pharmacol Sci. 2020;41(11):868–81.
Roever L, Resende ES, Alpert JS. Lipoprotein subfractions in type 2 diabetes. Heart Lung Circ. 2017;26(3):209–10.
Jawad H, Ali S, Jawad M. Impact of serum adiponectin level on insulin and hs-CRP in patients with type 2 diabetes: A case-control study. ASIDE Intern Med. 2025;1(1):20–3.